HORDB

ID: hor006015
Uniprot ID: P84901
Protein name: phyllokinin
Gene name: NA
Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)
Family: Bradykinin-related peptide family
Source: animal
Expression: Expressed by the skin glands.
Disease: NA
Comments: NA
Taxonomy: Pithecopus (genus), Phyllomedusinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0006952 defense response; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Function: Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). May target bradykinin receptors (BDKRB).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006015_AF2.pdb

hor006015_ESM.pdb

Mass:	152911	Formula:	C66H95N17O14
Absent amino acids:	ACDEHKLMNQSVW	Common amino acids:	P
pI:	11.15	Basic residues:	2
Polar residues:	3	Hydrophobic residues:	3
Hydrophobicity:	-55.45	Boman Index:	-2073
Half-Life:	1 hour	Half-Life Yeast:	2 min
Half-Life E.Coli:	2 min	Aliphatic Index	35.45
Instability Index:	6161.82	Extinction Coefficient cystines:	1490
Absorbance 280nm:	149